Specifying protein kinase C functions in melanoma
نویسندگان
چکیده
منابع مشابه
Isoform-specific functions of protein kinase C: the platelet paradigm.
Platelets are central to haemostasis and thrombosis. Many key steps in platelet activation and aggregation are regulated by members of the PKC (protein kinase C) family. Multiple isoforms of PKC are expressed in platelets, and evidence is emerging that different isoforms play distinct roles in the platelet activation process. This may, in part, be regulated by isoform-specific interactions betw...
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Cellular responses to environmental cues are mediated through complex networks of signal transduction pathways. Among the molecules involved in these pathways, members of the protein kinase C (PKC) family stand out because of their ability to acutely and reversibly modulate effector protein functions and control the spatial distribution and dynamic properties of the signals. PKC enzymes also co...
متن کاملTargeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms.
Protein kinase C lambda (PKClambda) is an atypical member of the PKC family of serine/threonine kinases with high similarity to the other atypical family member, PKCzeta. This similarity has made it difficult to determine specific roles for the individual atypical isoforms. Both PKClambda and PKCzeta have been implicated in the signal transduction, initiated by mediators of innate immunity, tha...
متن کاملTargeted Deletion of Protein Kinase C Reveals a Distribution of Functions between the Two Atypical Protein Kinase C Isoforms
Protein kinase C (PKC ) is an atypical member of the PKC family of serine/threonine kinases with high similarity to the other atypical family member, PKC . This similarity has made it difficult to determine specific roles for the individual atypical isoforms. Both PKC and PKC have been implicated in the signal transduction, initiated by mediators of innate immunity, that culminates in the activ...
متن کاملKinase-activity-independent functions of atypical protein kinase C in Drosophila.
Polarity of many cell types is controlled by a protein complex consisting of Bazooka/PAR-3 (Baz), PAR-6 and atypical protein kinase C (aPKC). In Drosophila, the Baz-PAR-6-aPKC complex is required for the control of cell polarity in the follicular epithelium, in ectodermal epithelia and neuroblasts. aPKC is the main signaling component of this complex that functions by phosphorylating downstream...
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ژورنال
عنوان ژورنال: Pigment Cell & Melanoma Research
سال: 2012
ISSN: 1755-1471
DOI: 10.1111/j.1755-148x.2012.01015.x